Melanostatine-5 | Nonapeptide-1
Melanostatine-5 is a synthetic peptide that mimics a part of the α-MSH sequence. By occupying the MC1-R receptor, it effectively blocks the action of α-MSH, reducing melanin production by up to 33%.
Directions:
Pour contents (100mg) into 2 oz serum for 5% active peptide.
Pour contents (200mg) into 2 oz serum for strong 10% active peptide.
Add as many peptides as desired.
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Buy Melanostatine-5
Overview: Melanostatine-5, also known as Nonapeptide-1, is a biomimetic peptide that serves as an antagonist to α-MSH (alpha-Melanocyte-Stimulating Hormone). It is specifically designed to inhibit melanin synthesis and prevent hyperpigmentation, making it an effective skin-lightening agent without cytotoxic effects on melanocytes.
Mechanism of Action: Melanostatine-5 works by blocking the activation of the MC1-R receptor on melanocytes, which prevents the activation of tyrosinase, a crucial enzyme in the melanin production pathway. This inhibition leads to a reduction in melanin synthesis, thereby decreasing pigmentation and promoting an even skin tone.
Benefits of Nonapeptide-1:
- Skin Lightening: Reduces sun spots, freckles, and other forms of hyperpigmentation, leading to a lighter and more uniform complexion.
- Safe and Effective: Does not interfere with the normal function of melanocytes, ensuring it is safe for regular use.
- Proven Results: Studies have shown significant improvement in skin lightening within 28 days of regular use
(www.personalcaremagazine.com). - Versatility: Suitable for various cosmetic formulations targeting skin brightening and evening skin tone
(Amvigor Organics -).
Usage:
- Concentration: Typically used in concentrations ranging from 4.0% to 8.0% in cosmetic formulations.
- Applications: Ideal for serums, creams, and other topical products aimed at reducing hyperpigmentation and promoting skin radiance.
Certifications:
- Preservative-free
- Vegan compatible
Scientific Background:
Melanostatine-5 is a synthetic peptide that mimics a part of the α-MSH sequence. By occupying the MC1-R receptor, it effectively blocks the action of α-MSH, reducing melanin production by up to 33% (INCI Guide).
Key Points of Melanostatine-5:
- Reduce hyperpigmentation and even out skin tone.
- Safe and lack of cytotoxic effects on melanocytes.
- Proven results and scientific backing.
- Compatible with various formulations and its preservative-free with vegan status.
- CAS158563-45-2
- SequenceMet-Pro-Phe-Arg-Trp-Phe-Lys-Pro-Val-NH2
- Molecular FormulaC61H87N15O9S
- Molecular Weight1206.50 g/mol
- PubChem CID4475164
- SynonymsNonapeptide-1
- Net Weight100mg, 200mg
- ManufacturerAminoBox
- Janet FerrisJul 16, 2024, 02:29Love this. really makes my skin so white n clear. the potency to this product compared to expensive 'sephora' brands is ridiculous. Makes me feel stupid for going there before when now i can quadruple doople the active peptide product and for a way more cost effective way.
Shipping Policy
Last Updated: May 11, 2026
Welcome to AminoBox. We are committed to providing fast, reliable shipping and maintaining the integrity of every order through careful packaging and handling.
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Orders are typically processed within 1–2 business days after payment confirmation.
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Select peptide products are shipped with insulated packaging and ice packs to help minimize heat exposure during transit.
While cold-chain packaging helps maintain product stability, temporary temperature fluctuations during shipping may occur and do not necessarily impact product quality.
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At AminoBox, customer satisfaction and product integrity are our top priorities. Due to the sensitive nature of research compounds and peptides, all sales are considered final unless otherwise stated below.
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For safety, quality control, and compliance reasons, we do not accept returns on opened, used, or temperature-sensitive products.
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Refunds are processed back to the original payment method whenever possible. Processing times may vary depending on your financial institution.
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Many products are shipped with ice packs to help preserve product integrity during transit. Thawing or melted ice packs upon arrival may occur and do not automatically indicate product damage.
Customers are responsible for ensuring someone is available to receive temperature-sensitive deliveries.
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Orders may only be canceled before fulfillment begins. Once an order has been processed or shipped, it cannot be canceled.
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Customers are responsible for providing accurate shipping details. AminoBox is not responsible for delays, losses, or delivery issues caused by incorrect addresses entered at checkout.
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If a package is marked as delivered by the carrier but cannot be located, customers should first contact the shipping carrier directly. We will do our best to assist where possible but cannot guarantee refunds for carrier-marked delivered packages.
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