Epitalon | AEDG
Epitalon increases telomerase activity in human somatic cells, leading to telomere elongation, which could prolong cell lifespan and delay aging processes.
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Epitalon is a synthetic tetrapeptide known for its potential anti-aging properties, primarily by activating telomerase, an enzyme that extends telomeres, which are protective caps on the ends of chromosomes. This activity is believed to slow down cellular aging and improve overall cell function. Epitalon was discovered by Russian scientist Vladimir Khavinson, and it has been extensively studied for its ability to extend lifespan, improve sleep quality, and enhance overall vitality.
The peptide has shown promising results in various studies. For instance, it has been reported to increase telomerase activity in human somatic cells, leading to telomere elongation, which could prolong cell lifespan and delay aging processes. Animal studies have indicated that Epitalon can extend lifespan by up to 32% and reduce the incidence of spontaneous tumors. In human studies, Epitalon has improved physical endurance, metabolic functions, and reduced mortality rates among patients with chronic diseases.
Anti-Aging Benefits
Telomere Maintenance: Telomeres are protective caps at the ends of chromosomes that shorten as cells divide. This shortening process is associated with aging and cellular dysfunction. Epitalon has been shown to activate telomerase, the enzyme responsible for elongating telomeres, thereby delaying the aging process at the cellular level. Studies indicate that this mechanism can extend the lifespan of cells, contributing to overall longevity (Wikipedia Epitalon, The Amino Company).
Improved Sleep Quality: Epitalon has been shown to regulate the production of melatonin, a hormone that controls the sleep-wake cycle. Enhanced melatonin production can lead to better sleep quality, which is crucial for cellular repair and regeneration. Improved sleep is directly linked to better skin health and overall vitality.
Antioxidant Properties: Epitalon exhibits antioxidant effects, reducing lipid peroxidation and stabilizing red blood cell membranes. This antioxidant activity helps in neutralizing free radicals, which are responsible for cellular damage and aging. By mitigating oxidative stress, Epitalon contributes to healthier and more youthful-looking skin (World of Peptides).
Beauty Benefits
Skin Health and Appearance: Through its action on telomeres and its antioxidant properties, Epitalon promotes healthier skin by supporting cellular repair and reducing signs of aging such as wrinkles and fine lines. Enhanced telomerase activity ensures that skin cells remain youthful and functional for a longer period (Cayman Chemical).
Enhanced Collagen Production: Although not directly linked to collagen synthesis, the improved cellular function and reduced oxidative stress from Epitalon use can indirectly support better collagen maintenance. Collagen is a crucial protein for skin elasticity and firmness, and its degradation leads to sagging skin and wrinkles. By maintaining cellular health, Epitalon can help preserve collagen levels (Antiaging Systems).
Regulation of Circadian Rhythms: The regulation of melatonin production not only improves sleep but also synchronizes the body’s internal clock, which can impact overall skin health. Good sleep is essential for skin regeneration and repair processes that occur predominantly during the night.
Summary Table
Serial Number | Paper Title | Insight | Citation Count |
---|---|---|---|
1 | Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells (Khavinson, 2003) | Demonstrated telomerase activation and telomere elongation, suggesting potential anti-aging benefits. | - |
2 | Effect of Ala-Glu-Asp-Gly peptide on lifespan and tumor development in rats (Vinogradova, 2007) | Reported lifespan extension and reduced tumor incidence in animal models. | - |
3 | Epitalon in Longevity and Anti-Aging Research (Anisimov & Khavinson, 2009) | Extensive review of peptide bioregulators and their applications in aging and cancer prevention. | - |
4 | Antioxidant properties of geroprotective peptides of the pineal gland (Kozina, 2007) | Highlighted the antioxidant effects of Epitalon, which stabilize cell membranes and reduce oxidative damage. | - |
5 | Peptides and aging: literature review and own data (Khavinson, 2014) | Discussed molecular markers of aging and the potential of peptides like Epitalon to influence aging processes. | - |
- Amino SequenceH-Ala-Glu-Asp-Gly-OH
- Molecular FormulaC14H22N4O9
- PubChem CID219042
- Molecular Weight390.35 g/mol
- CAS307297-39-8
- SynonmsEpithalon
Epithalamin
Epithalamine
Epithalon
AE-0 peptide - ManufacturerAMINOBOX
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