Compound 7P and Anti-Aging

Overview:

Compound 7P is a nootropic compound initially developed to support neurite outgrowth and cognitive enhancement. Recent research is exploring its potential role in promoting axonal regeneration, which has significant implications for anti-aging skincare. Degeneration of axons can occur due to trauma, neurological diseases, and aging. Neurons typically cannot repair or regenerate themselves without external assistance, leading to skin aging and deterioration.

Mechanisms of Action: 

Effective axonal regeneration often involves manipulating specific signaling pathways. The most prevalent mechanisms include epigenetic regulation of gene transcription, development-dependent transcription, and the mTOR and STAT3 pathways. Researchers have discovered that altering the expression of these pathways can effectively lead to axon regeneration in the central nervous system (CNS).

Building on this research, additional modalities have been explored to promote axon growth. Using phenotypic cell-based screens, researchers can visually assess and measure in vitro neurite outgrowth. This method allows for identifying different protein targets and understanding various signalling pathways' mechanisms. Tracking axon elongation via phenotypic small screens provides an opportunity to pharmacologically manipulate factors assisting in axon regeneration.

Use of Compound 7P in Anti-Aging Skincare:

 Compound 7P has shown promise in promoting neurite outgrowth in primary neurons of the hippocampus, cerebral cortex, and retina. This regenerative capability can be translated into skin health applications, where it may help rejuvenate and repair damaged cells.

Research Findings:

• Optic Nerve Regeneration: In studies, Compound 7P improved neurite outgrowth and induced optic nerve regeneration in animal models of injury. This suggests potential benefits for treating damaged cells by environmental stressors and aging.
• Cellular Effects: When treated with Compound 7P, retina neuronal cells exhibited significant axon growth, with the most considerable increase at a 10 μM dose. This enhanced cellular growth and regeneration can translate to improved vitality and resilience.

Potential in Anti-Aging Products:

• Anti-Aging: Promotes cellular regeneration.
• Skin Repair: Aids in recovery from environmental damage and aging.
• Collagen Production: Enhances collagen synthesis, improving skin elasticity and firmness.

Future Research of Compound 7P: 

Further studies are needed to understand how Compound 7P can be optimized for anti-aging. Research into its mechanisms and effective dosages will help develop more targeted and efficient anti-aging treatments.

References:

• Inflammation and Regeneration Journal discusses various aspects of axon regeneration, including signaling pathways and research methodologies.
• Boost Your Biology highlights the potential of Compound 7P in promoting neurite outgrowth and its broader implications for neuroregeneration and skincare.